Year: 2017 | Month: February | Volume 7 | Issue 1

Effect of Vitamin E and Selenium Supplementation on Arsenic Induced Oxidative Stress in Goats


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Abstract:

Present study was designed to assess the effect of vitamin E+Se supplementation on growth performance as well as antioxidant status in arsenic toxicity in experimental goats. Eighteen cross breed goats of either sex, aged between 12 to 24 months of age were randomly selected and divided into three groups. Group I was considered as healthy control. Goats of group II and III received Sodium arsenite (NaAsO2) @ 5 mg/kg orally daily for 45 days. The goats of group III also received the treatment of Vitamin E+Se. Increase growth performance was observed in animals supplemented with Vitamin E+Se treatment as compared to group II animals. Significantly (P<0.05) increased lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) enzyme activity in blood, liver and kidney tissue were observed in arsenic intoxicated goats. However, arsenic treatment caused depletion of reduced glutathione (GSH). Restoration of arsenic toxicity effects were observed in group III animals. (Kile et al., 2007) Therefore, present study indicated the ameliorative potential of Vitamin E + Se against toxic effects of arsenic.



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