Year: 2022 | Month: February | Volume 12 | Issue 1

Collagen Encapsulated Oral Newcastle Disease Vaccine Induces Protective Antibody Response in Backyard Poultry

Madhanmohan Muthukrishnan K. Chitra R.P. Aravindh Babu S. Sivaseelan T.M.A. Senthilkumar G. Dhinakar Raj


Newcastle disease (ND) is endemic in India and outbreaks are recorded throughout the year in commercial and backyard poultry farms. The aim of the study was to evaluate the acceptability, safety and immunogenicity of orally administrated live ND vaccine encapsulated in collagen beads to backyard poultry under field conditions. The birds were randomly divided into two groups of each 100 birds. In group 1, live lentogenic ND LaSota vaccine encapsulated in collagen beads (NDV-CG-BDs) were administrated orally at 21 days of age. In group 2, all the birds were vaccinated on 21 days of age with the same batch of live lentogenic ND LaSota vaccine using drinking water. The Newcastle disease humoral antibody response was assessed using haemagglutination inhibition (HI) test. The chicks readily taken the live lentogenic Newcastle disease LaSota vaccine encapsulated in collagen beads (NDV-CG-BDs). There were no untoward reactions or mortality throughout the study period of 90 days. There was no significant (P>0.05) difference in body weight observed between the groups during the study period. There was no significant difference (p>0.05) of mean HI titers in NDV-CG-BDs group in comparison with NDV vaccine administered through water on 7,14,28,45,90 days post vaccination. The protective HI titer of ≥ Log24 was observed from 7th days post vaccination and maintained up to 90 days post vaccination in both the vaccinated groups. In conclusion, the poultry farmers can easily adopt the procedure at the farm site and control the Newcastle disease in backyard poultry.


  • Collagen encapsulated oral Newcastle disease vaccine induced protective antibody response in backyard poultry.
  • The protective antibody titer was maintained up to 90 days post vaccination.

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@ Journal of Animal Research | In Association with Association of Mastitis

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