Year: 2022 | Month: October | Volume 12 | Issue 5

Effects of Nanonickel Administration on Biochemical Parameters in Wistar Rats

Jitendra Singh Munish Batra Tushar Gupta Neeraj Kumar


Nanomaterial applications are a field which is rapidly growing. Despite the growing use of nickel oxide nanoparticles, there is little knowledge on their toxicological impact. Despite their powerful advantages, many open ended questions about how these nanoparticles can affect the environment and human health. Present study was conducted to know the effects of nanonickel on biochemical parameters in Wistar rat at NOAEL dose for a period of 90 days. Thirty five, six weeks old, Wistar rats of both sexes were divided randomly in two groups viz. group I with 20 rats as control group and group II with 15 rats as treatment group. Group II was orally administered nickel oxide nanoparticles of less than 50 nm diameter in distilled water at NOAEL dose of 5 mg/kg body weight/day and these were gavaged once daily for 90 days. Blood was collected by cardiac puncture from 5 rats from each group at 0 (only from group I), 30th, 60th and 90th DPT and serum was used for biochemical studies. Group I rats revealed no significant change in any biochemical parameter. Group II rats showed a significant increase in serum creatinine, serum aspartate aminotransaminase (AST) and serum alanine aminotransaminase (ALT), significant decrease in total protein and gamma globulin and non significant increase in glucose and globulin values as compared to control group. It can be concluded from the present studies that nanonickel exerted adverse effects on these biochemical parameters in Wistar rats at NOAEL dose administered for a period of 90 days. Our research stated that nickel nano-particles adversely alter rats biochemical profile. Further investigations to address the mechanism are required by what physiological path these nano-nickel display their in vivo toxicity.


  • Effect of nickel nano-particles is well defined on biochemical parameters of Wistar rats.
  • Nickel nanoparticle severely effects biochemical profile of laboratory animals.

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