In the present investigation, a total of twelve dogs found positive for acute liver failure and 6 healthy dogs were selected for therapeutic study. Six dogs were considered in apparently healthy control group (group I) after thorough physical examination and various diagnostic tests. Affected twelve dogs were randomly divided into two groups (group II and group III) six animal each. In group II conventional treatment was given and in group III conventional treatment with combination of Moringa oleifera @ 30 mg/kg body weight PO was administered for 14 days. Therapeutic evaluation was done on the basis of percent recovery assessment. Percent recovery was assessed by clinical improvement in terms of disappearance of clinical signs and alterations in the hemato-biochemical parameters on day 7th and day 14th post treatment. Complete clinical examination of all dogs of acute liver failure was made. ALF cases had significantly higher levels of ALT, AST, ALP, GGT, serum total bilurubin and cholesterol than the healthy animal group, whereas serum total protein, albumin and glucose found significantly in lower levels. Both conventional therapy as well as combination of Moringa oleifera with conventional therapy was found effective against acute liver failure in dogs as evidenced by restoration of ALT, AST, ALP, GGT, total protein, cholesterol, bilirubin and glucose. Based on results of the study it was concluded that Moringa oleifera may be advised as adjunct therapy along with conventional treatment for early recovery in acute liver failure in dogs.

Highlights

• The study focused on therapeutic efficacy of Moringa oleifera leaves on acute liver failure (ALF) in dogs.
• Moringa oleifera helps in reduction of ALT, AST, ALP and GGT levels in dogs.
• It may be recommended as adjunct therapy in acute liver failure in dogs along with standard treatment for early recovery.