Year: 2019 | Month: April | Volume 9 | Issue 2
Ameliorating Potential of Panax Ginseng on Oxidative Stress following Subacute Exposure to Acetamiprid in Rats
Abstract:
Oxidative stress is common when the cellular antioxidant capacity is overwhelmed by the reactive oxygen species generated by the metabolism of pesticides which either inhibit or modulate the expression of antioxidant enzymes. The present study was made with objective to evaluate the ameliorating potential of Panax ginseng on oxidative stress following subacute exposure to Acetamiprid in rats. Twenty four adult male Wistar rats were divided in four groups comprising six each. Group I served as control and was administered with groundnut oil (1ml/100gm), group II was administered with Acetamiprid (52.5 mg/kg body weight), group III served as Panax ginseng (50 mg/kg body weight) control and in group IV possible ameliorative effect of Panax ginseng was examined against Acetamiprid. Vehicle, Acetamiprid and Panax ginseng were administered daily to the rats orally by gavage for 28 days and animals were sacrificed at the end. Liver, kidney, spleen and brain were processed for determination of oxidative stress related parameters viz: Lipid peroxidation (LPO), reduced glutathione (GSH), Superoxide dismutase (SOD), catalase and glutathione reductase (GR) levels. Acetamiprid produced toxicity which was evident in the form of enhanced lipid peroxidation and decrease in activities of GSH, SOD, catalase and glutathione reductase levels in all the organs examined. Panax ginseng was significantly effective in restoration of these parameters towards normal. Thus, it was concluded that Panax ginseng has ameliorating potential on oxidative stress following subacute exposure to acetamiprid in rats
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