Leptospirosis is a zoonotic infectious disease of worldwide economic importance affecting both humans and animals. It is bacterial disease caused by spirochete of genus Leptospira. The symptom ranges from flu-like illness to acute kidney failure, jaundice in humans while it causes abortions, stillbirths, reduced milk production in animals. Rodents, domestic and wild animals act as carrier and excrete live organism is their urine. It is an occupational disease affecting farmers, veterinarians, slaughterhouse workers, etc those who are in direct or indirect contact with the carrier animals. The diagnosis is done by direct and indirect laboratory methods for detection of infectious agent and its antibodies. The disease can be controlled through vaccination of domestic animals, control of rodents, strict and proper environmental hygienic measures.