Year: 2021 | Month: December | Volume 11 | Issue 6
Anti-inflammatory Potential of Whole Pomegranate Fruit Juice (POM) against Bleomycin Induced Lung Injury in Rats
Shaik Maimonaparveen
D. Madhuri
M. Lakshman
B. Anilkumar
DOI:10.30954/2277-940X.06.2021.6
Abstract:
The ameliorative potential of whole Pomegranate fruit juice was studied against Bleomycin (BLM) induced lung injury. A total of 48 male Wistar albino rats were procured and divided into 4 groups consisting of 12 rats in each. The group 1 (control), group 2 BLM toxic control {@ 5 mg/kg body weight (b.wt) via single intra- tracheal (IT) instillation}, group 3 administered with BLM (@ 5 mg/kg b.wt via single IT instillation) and Pomegranate juice (@ 1 mL/rat once daily orally) and group 4 rats administered with Pomegranate juice only (@ 1 mL/rat once daily orally). Grossly, in group 2 rats, lung showed congestion, haemorrhage and edema. Histopathological studies revealed interstitial pneumonia, pulmonary edema, neutrophilic infiltration in perivascular and peribronchiolar areas on 14th day of experiment. In addition to these lesions complete loss of architecture of lung alveoli, severe hyperplasia of bronchiolar epithelial cells, peribronchiolar infiltration and mild fibrosis in perivascular and peribronchiolar areas was noticed on 28th day of experiment. Group 3 rats showed moderate improvement in both gross and histopathological lesions. The cytokine activity in group 2 showed a significant (P<0.05) increase in tumor necrosis factor- Alpha (TNF-α), transforming growth factor-Beta 1 (TGF-β1) and interleukin (IL)-10 while treatment with POM in group 3 exhibited significant decreased in the levels of proinflammatory cytokines. The current study concluded the anti-inflammatory effect of POM against bleomycin.
Highlights
- Inflammatory cytokines play important role in the pathogenesis of pulmonary toxicity.
- Pomegranate fruit juice showed significant anti-inflammatory activity.
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