Year: 2022 | Month: April | Volume 12 | Issue 2
Efficacy of Lactoferrin with Dexamethasone Sodium on Hematological Profile Against Acetic Acid Induced Colitis in Rats
Lavudya Naveen
Ashok Kumar Devarasetti
Akkaladevi Jayasri
Alla Gopala Reddy
Mohammed Shaz Murtuza
DOI:10.30954/2277-940X.02.2022.23
Abstract:
Lactoferrin (Lf) is a member of transferrin family. It is a glycoprotein that binds mainly to iron. Lf is present in exocrine secretions and it has been reported to have various defensive function. The present study was aimed to evaluate the hematological parameters when lactoferrin (@ 200 mg/kg b.wt.) was administered orally in acetic acid-induced colitis (4% @ 2 ml single dose intra-colonic) in rats. Hematological parameters revealed that, the means of Total Leucocyte Count (TLC) and Differential Leucocyte Count (DLC) were improved significantly (P < 0.05) in Lf treated group. The results were suggested that, Lf has positive effect on hematological profile on acetic acid - induced colitis in rats. Therefore, Lf is a promising potential therapeutic agent for the treatment of colitis.
Highlights
- Total leucocyte count, neutrophil and eosinophil count increased significantly in rats treated with 4% acetic acid.
- Lactoferrin-treated groups had a faster return to near-normal haematological parameters on the 14th day.
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