Year: 2022 | Month: August | 12 | 4
Cadmium and Thiram Induced Nephrotoxicity in Experimental Broiler Chicken
A. Uma Choudary
M. Lakshman
D. Madhuri
Banothu Anilkumar
Y. Ravikumar
DOI:10.30954/2277-940X.04.2022.9
Abstract:
The experiment was designed to study TMTD and CdCl2-induced toxicity in broiler birds. 100-day-old chicks were distributed into 4 groups of 25 each. Group 1 birds were fed with a basal diet, group 2 fed with 60 ppm of TMTD, group 3 fed with 100 ppm of CdCl2 and group 4 fed with TMTD + CdCl2 for 35 days. Six birds from each group were sacrificed on the 14th, 28th and 42nd day of the experiment and the serum samples were collected. Significantly, increased levels in serum creatinine, uric acid and TBARS and decreased levels of GSH in groups 2, 3, and 4 were recorded on the 14th, 28th and 42nd day. Kidney sections showed degeneration followed by desquamation of cells and presence of casts on the 14th day, severe congestion of renal artery, and intertubular haemorrhages were observed on the 28th day. Additional lesions like degeneration of tubular epithelial cells with pyknotic nuclei, swollen to shrunken glomeruli with hypercellularity and increased Bowman’s space were also observed on the 42nd day of the experiment. In conclusion, the present study suggested that TMTD, CdCl2 and its combination are responsible for significant changes which could be due to free radicals which led to impairment of antioxidant defences and resulted in macroscopic and microscopic pathological changes in kidneys.
Highlights
- TMTD and CdCl2 causes changes in the kidney due to release of free radicals.
- The occurrence of mixed toxicity could be possible due to increased environmental pollutants (Industrial and Agricultural) in developing countries more particularly in India.
- The combined toxicity is more severe than individual toxicity and envisages the synergistic action of the toxicants.
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